Anti-troponin I antibodies in renal transplant patients

• Type: Article in International Scientific Journal
• Date: 2015

Authors

José Pedro Nunes (Author) FMUP; Sampaio, S (Author) FMUP; Cerqueira, A (Author) Other; Kaya, Z (Author) Other; Oliveira, NP (Author) Other

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 34

Pages: 85-89

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-00A-6KP

DOI: 10.1016/j.repc.2014.08.018

Abstract (EN): Objective: To characterize the prevalence and clinical correlates of anti-troponin I antibodies in renal transplant patients. Methods: A group of 48 consecutive renal transplant patients under immunosuppressive therapy were studied. Anti-troponin I antibodies were measured and clinical data were retrieved. Results: An anti-troponin I antibody titer <1:40 was seen in most patients (30). IgG antibody titers >= 1:80 were seen in eight patients, with a single value of 1:160. Regarding IgM antibodies, in six cases titers >= 1:80 were seen, with one value of 1:320. In only one patient were both anti-troponin I antibody IgG and IgM titers 1:80 or higher. Clinical cardiac disease was seen in nine patients. The presence of an anti-troponin I antibody titer >= 1:80 was not associated with the presence of clinical cardiac disease (p=0.232), but was associated with statin therapy status (p=0.008), being less frequent in patients under statin therapy. Conclusions: Anti-troponin I antibodies are seen in a minority of renal transplant patients, and are not associated with the presence of clinical heart disease, but are associated with lack of statin therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5