Prevalence of auto-antibodies associated to pulmonary arterial hypertension Cheek for in scleroderma - A review

• Type: Article in International Scientific Journal
• Date: 2018

Authors

José Pedro Nunes (Author) FMUP; Cunha, AC (Author) Other; Meirinhos, T (Author) Other; Nunes, A (Author) Other; Araujo, PM (Author) Other; Godinho, AR (Author) Other; Vilela, EM (Author) Other; Carlos Vaz (Author) FMUP

Journal

Title: Autoimmunity Reviews

Vol. 17

Pages: 1186-1201

ISSN: 1568-9972

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 43 Citations

Other information

Authenticus ID: P-00P-TND

DOI: 10.1016/j.autrev.2018.06.009

Abstract (EN): The prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma patients was reviewed, based on reports cited in two major scientific databases. Data were collected on the following types of antibodies: antinuclear, anti-double-stranded DNA, anticentromere, anti-CENP-A, anti-CENP-B, anti-bicaudal D2, anti-nucleolar, anti-Scl-70 (anti-topoisomerase I), anti-topoisomerase II alpha, anti-RNP, anti-U1RNP, anti-U3RNP, anti-RNA polymerase III, anti-Th/To, anti-histone, antiphospholipid, anti-PmScl, anti-Sm, anti SSA (anti-Ro),anti SSB (La), anti-Ro52 (TRIM 21), anti-Ku, anti-B23, anti-RuvBL1, anti-RuvBL2, anti-fibrin bound tissue plasminogen activator, anti-endothelial cell, anti-phosphatidylserine-prothrombin complex, anti-endothelin-1 type A receptor, anti-angiotensin II type 1 receptor, anti-carbonic anhydrase II, anti-fibroblast, anti-cyclic citrullinated peptide, anti-4-sulfated N-Acetyl-lactosamine, class I and II anti-human leukocyte antigen. Auto-antibodies were shown by different authors to be associated to this condition, with different prevalence values for each type of auto-antibody. Antinuclear antibodies, anti-centromere antibodies, antiphospholipid antibodies, anti-U3 RNP antibodies and anti-Th/To antibodies would appear to show a particularly important prevalence in scleroderma patients with pulmonary hypertension, appearing in about 8/10 (antinuclear), 1/2 (anti-centromere, anti-phospholipid), and 1/4 (anti-U3RNP, anti-Th/To) of patients. The available evidence points in the direction of a strong association between auto-immune mechanisms and pulmonary hypertension in the setting of scleroderma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16