Museomics Dissects the Genetic Basis for Adaptive Seasonal Coloration in the Least Weasel

• Type: Article in International Scientific Journal
• Date: 2021-06-22

Authors

Inês Miranda (Author) FCUP; Iwona Giska (Author) Other; Liliana Farelo (Author) Other; João Pimenta (Author) FCUP; Marketa Zimova (Author) Other; Jaroslaw Bryk (Author) Other; Love Dalén (Author) Other; L. Scott Mills (Author) Other; Karol Zub (Author) Other; José Melo-Ferreira (Author) FCUP

Journal

Title: Molecular Biology and Evolution

Vol. 38 No. 10

Pages: 4388-4402

ISSN: 0737-4038

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-00V-MER

DOI: 10.1093/molbev/msab177

Abstract (EN): Dissecting the link between genetic variation and adaptive phenotypes provides outstanding opportunities to understand fundamental evolutionary processes. Here, we use a museomics approach to investigate the genetic basis and evolution of winter coat coloration morphs in least weasels (Mustela nivalis), a repeated adaptation for camouflage in mammals with seasonal pelage color moults across regions with varying winter snow. Whole-genome sequence data were obtained from biological collections and mapped onto a newly assembled reference genome for the species. Sampling represented two replicate transition zones between nivalis and vulgaris coloration morphs in Europe, which typically develop white or brown winter coats, respectively. Population analyses showed that the morph distribution across transition zones is not a by-product of historical structure. Association scans linked a 200-kb genomic region to coloration morph, which was validated by genotyping museum specimens from intermorph experimental crosses. Genotyping the wild populations narrowed down the association to pigmentation gene MC1R and pinpointed a candidate amino acid change cosegregating with coloration morph. This polymorphism replaces an ancestral leucine residue by lysine at the start of the first extracellular loop of the protein in the vulgaris morph. A selective sweep signature overlapped the association region in vulgaris, suggesting that past adaptation favored winter-brown morphs and can anchor future adaptive responses to decreasing winter snow. Using biological collections as valuable resources to study natural adaptations, our study showed a new evolutionary route generating winter color variation in mammals and that seasonal camouflage can be modulated by changes at single key genes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15