Effects of early intravesical administration of resiniferatoxin to spinal cord-injured rats in neurogenic detrusor overactivity

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Oliveira, R (Author) Other; Coelho, A (Author) Other; Franquinho, F (Author) Other; Sousa, MM (Author) Other; Francisco Cruz (Author) FMUP; Cruz C.D. (Author) FMUP

Journal

Title: Neurourology and Urodynamics

Vol. 38

Pages: 1540-1550

ISSN: 0733-2467

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00Q-WDG

DOI: 10.1002/nau.24032

Abstract (EN): Objectives To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. Materials and Methods Rats submitted to largely incomplete spinal cord transection at T8/9 spinal segment were treated with intravesical RTX (50 nM) or its vehicle during spinal shock. Four weeks after spinal lesion, bladder-reflex activity was evaluated by cystometry under urethane anesthesia, after which the bladder, spinal cord, and dorsal root ganglia were collected and processed. Results We found improvements on bladder function several weeks after early intravesical RTX administration, including a marked decrease of intravesical pressures and amplitude of bladder contractions. Such strong long-lasting urodynamic effects resulted from the very potent desensitizing activity of RTX on peripheral terminals of sensory afferents, an effect restricted to the bladder. Conclusion Our results support that an early intervention with RTX could potentially attenuate NDO development and ensuing urinary incontinence, with a dramatic impact on the quality of life of spinal cord injury patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11