Biomarkers of spinal cord injury and ensuing bladder dysfunction

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Cruz C.D. (Author) FMUP; Coelho, A (Author) Other; Antunes Lopes, T (Author) FMUP; Francisco Cruz (Author) FMUP

Journal

Title: Advanced Drug Delivery Reviews

Vol. 82-83

Pages: 153-159

ISSN: 0169-409X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-00A-AZA

DOI: 10.1016/j.addr.2014.11.007

Abstract (EN): During the acute phase of SCI, the extension and residual neurological deficits that will persist after the waning of the spinal shock period are difficult to estimate on clinical grounds. Therefore, objective biomarkers able to estimate the extension of the lesion and the degree of neurological recovery are of great importance. Research has been focused on the detection of structural neuronal and glial proteins that leak from damaged cells, inflammatory proteins recruited to remove necrotic debris and more accurate neuroimaging methods that are able to discriminate the extension and functional consequences of the SCI. Urinary biomarkers are also being investigated to estimate functional changes that typically affect bladder function following SCI which can endanger patient's life in the long run. Future studies are needed to precisely characterize the composition and function of the glial scar that appears in the area of SCI and repeals axonal growth, therefore preventing axonal rewiring.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7