Graphene Oxide Topical Administration: Skin Permeability Studies

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Filipa A. L. S. Silva (Author) Other; Raquel Costa Almeida (Author) Other; Licínia Timochenco (Author) Other; Sara I. Amaral (Author) Other; Soraia Pinto (Author) Other; Inês C. Gonçalves (Author) Other; José R. Fernandes (Author) Other; Fernão D. Magalhães (Author) FEUP; Bruno Sarmento (Author) Other; Artur M. Pinto (Author) Other

Journal

Title: Materials

Vol. 14 No. 19

Pages: 1-2810

ISSN: 1996-1944

Publisher: MDPI

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00V-1QY

DOI: 10.3390/ma14112810

Abstract (EN): Nanostructured carriers have been widely used in pharmaceutical formulations for dermatological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size and photothermal properties, graphene oxide (GO) has the potential to be used for such applications. Nanographene oxide (GOn) presented average sizes of 197.6 +/- 11.8 nm, and a surface charge of -39.4 +/- 1.8 mV, being stable in water for over 6 months. 55.5% of the mass of GOn dispersion (at a concentration of 1000 mu g mL(-1)) permeated the skin after 6 h of exposure. GOn dispersions have been shown to absorb near-infrared radiation, reaching temperatures up to 45.7 degrees C, within mild the photothermal therapy temperature range. Furthermore, GOn in amounts superior to those which could permeate the skin were shown not to affect human skin fibroblasts (HFF-1) morphology or viability, after 24 h of incubation. Due to its large size, no skin permeation was observed for graphite particles in aqueous dispersions stabilized with Pluronic P-123 (Gt-P-123). Altogether, for the first time, Gon's potential as a topic administration agent and for delivery of photothermal therapy has been demonstrated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15