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Synthesis of methyl (+/-)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics

Title
Synthesis of methyl (+/-)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics
Type
Article in International Scientific Journal
Year
2010
Authors
Joana F Ferreira da Costa
(Author)
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Olga Caamano
(Author)
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Franco Fernandez
(Author)
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Xerardo Garcia Mera
(Author)
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Pilar Midon
(Author)
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Jose Enrique Rodriguez Borges
(Author)
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Journal
Title: TetrahedronImported from Authenticus Search for Journal Publications
Vol. 66 No. 34
Pages: 6797-6805
ISSN: 0040-4020
Publisher: Elsevier
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-003-3Y8
Abstract (EN): Starting from readily available N-benzyl protected methyl 3,5-bis(hydroxymethyl)pirrolidinecarboxylate a number of racemic methyl t-3,t-5-disubstitutedprolinates have been synthesised, thus opening a practical way towards the preparation of a variety of putative proline-mimetics. In this context, N-Boc protected derivatives proved to be better intermediates than their N-benzyl counterparts in terms of cleanness and overall yield of the synthetic procedure.
Language: English
Type (Professor's evaluation): Scientific
Contact: molga.caamano@usc.es
No. of pages: 9
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