Diagnostic and treatment approaches to mastocytosis - A proposal for clinical guidelines [Abordagem diagnóstica e terapêutica das mastocitoses - Uma proposta de orientação clínica]

• Type: Article in National Scientific Journal
• Date: 2020

Authors

Tiago Rama (Author) FMUP; Moreira, A (Author) Other; Delgado, L (Author) FMUP

Journal

Title: Revista Portuguesa de Imunoalergologia

Vol. 28 No. 1

Pages: 31-49

ISSN: 0871-9721

Publisher: Publicacoes Ciencia e Vida

Indexing

Scopus - 2 Citations

Other information

Authenticus ID: P-00S-1WX

DOI: 10.32932/rpia.2020.03.030

Abstract (EN): Mastocytosis are a heterogeneous group of rare clonal mast cell diseases. In the past, mastocytosis management included a strict avoidance of all drugs, contrast media, foods and procedures ever described as mast cell activators. In the present, several international guidelines have emerged, proposing a more tailored approach, however in Portugal there are no current clinical guidelines. This proposal for management of mastocytosis intends to offer guidelines to the Portuguese clinician. Diagnosis should be based on a skin biopsy (when there are skin lesions) and on bone marrow examination. All patients should have documentation on their disease and triggers that should be avoided. Treatment should be personalized and may include cromolyn sodium, H1 and/or H2 antihistamines, among others. Patients should be given premedication protocols to be implemented before surgical procedures, labour and use of iodinated contrast media.

Language: Portuguese

Type (Professor's evaluation): Scientific