Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Ferreira Duarte, M (Author) Other; Sousa, JB (Author) Other; Diniz, C (Author) FFUP; Sousa, T (Author) FMUP; Duarte Araujo, M (Author) Other; Morato, M (Author) FFUP

Journal

Title: Current Pharmaceutical Design

Vol. 26

Pages: 3733-3747

ISSN: 1381-6128

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00S-QZD

DOI: 10.2174/1381612826666200701212414

Abstract (EN): The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15