A Panel of Urinary Volatile Biomarkers for Differential Diagnosis of Prostate Cancer from Other Urological Cancers

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Lima, AR (Author) Other; Pinto, J (Author) Other; Carvalho Maia, C (Author) Other; Carmen Jeronimo (Author) ICBAS; henrique, rmf (Author) ICBAS; Maria de Lourdes Bastos (Author) FFUP; Carvalho, M (Author) Other; Guedes de Pinho, PG (Author) FCUP

Journal

Title: Cancers

Vol. 12

Pages: 1-8

ISSN: 2072-6694

Publisher: MDPI

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00S-GXH

DOI: 10.3390/cancers12082017

Abstract (EN): Our group recently developed a urinary 6-biomarker panel for the diagnosis of prostate cancer (PCa) which has a higher level of accuracy compared to the serum prostate specific antigen (PSA) test. Herein, urine from an independent cohort of PCa patients and cancer-free controls was analyzed to further validate the discriminative power of that panel. Additionally, urine from patients diagnosed with bladder cancer (BC) and renal cancer (RC) were included to evaluate the site-specificity of the panel. Results confirmed the ability of the 6-biomarker panel to discriminate PCa patients from controls, but not from other urological cancers. To overcome this limitation, an untargeted approach was performed to unveil discriminant metabolites among the three cancer types. A 10-biomarker panel comprising the original panel plus four new metabolites was established to discriminate PCa from controls, BC, and RC, with 76% sensitivity, 90% specificity, and 92% accuracy. This improved panel also disclosed better accuracy than serum PSA test and provides the basis for a new non-invasive early detection tool for PCa.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8