Computational Studies of the Luciferase Light-Emitting Product: Oxyluciferin

• Type: Article in International Scientific Journal
• Date: 2011

Authors

da silva, lp (Author) Other; da silva, jcge (Author) FCUP

Journal

Title: Journal of Chemical Theory and Computation

Vol. 7 No. 4

Pages: 809-817

ISSN: 1549-9618

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 68 Citations

Scopus - 75 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry > Analytical chemistry > Spectrochemistry

Other information

Authenticus ID: P-002-SQV

DOI: 10.1021/ct200003u

Abstract (EN): Firefly luciferase is the most studied bioluminescence system, and its catalyzed reactions have been relatively well characterized. However, the color tuning mechanism that leads to firefly multicolor bioluminescence is still unknown, nor is consensual which is the yellow-green and red emitters. Computational studies have been essential in the study of oxyluciferin (OxyLH(2)) chemi- and bioluminescence and are responsible for most of our knowledge of this natural phenomenon. The objective of this manuscript is the analysis of the benefits and the conclusions derived from the theoretical studies of the light emitter, OxyLH(2), and its applications on bioluminescence research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9