Sensibility of the quorum growth thresholds controlling local immune responses Q

• Type: Article in International Scientific Journal
• Date: 2008

Authors

N. J. Burroughs (Author) Other; B. M. P. M. Oliveira (Author) Other; A. A. Pinto (Author) FCUP; H. J. T. Sequeira, (Author) Other

Journal

Title: Mathematical and Computer Modelling

Vol. 47

Pages: 714-725

ISSN: 0895-7177

Publisher: Pergamon Press - Elsevier

Scientific classification

CORDIS: Physical sciences > Mathematics

FOS: Natural sciences > Mathematics

Other information

Resumo (PT): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Language: English

Type (Professor's evaluation): Scientific

Notes: Q