Transgenerational inheritance of chemical-induced signature: A case study with simvastatin

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Neuparth, T (Author) Other; Machado, AM (Author) Other; Montes, R (Author) Other; Rodil, R (Author) Other; Barros, S (Author) FCUP; Alves, N (Author) Other; Ruivo, R (Author) Other; Filipe F C Castro (Author) FCUP; Quintana, JB (Author) Other; Santos, MM (Author) FCUP

Journal

Title: Environment International

Vol. 144

ISSN: 0160-4120

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00S-MHM

DOI: 10.1016/j.envint.2020.106020

Abstract (EN): The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and adverse outcomes. We demonstrate here reproductive multi and transgenerational effects, at environmentally relevant levels, of one of the most prescribed human pharmaceuticals, simvastatin, in a keystone species, the amphipod Gammarus locusta. The transgenerational findings has major implications for hazard and risk assessment of pharmaceuticals and other contaminants of emerging concern given that transgenerational effects of environmental chemicals are not addressed in current hazard and risk assessment schemes. Considering that the mevalonate synthesis, one of the key metabolic pathways targeted by simvastatin, is highly conserved among metazoans, these results may also shed light on the potential transgenerational effects of simvastatin on other animals, including humans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10