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Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention strategies

Title
Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention strategies
Type
Another Publication in an International Scientific Journal
Year
2013
Authors
Rui Adao
(Author)
Other
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Gilles de Keulenaer
(Author)
Other
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Adelino Leite Moreira
(Author)
FMUP
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Carmen Bras Silva
(Author)
FMUP
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Journal
Vol. 32 No. 9
Pages: 395-409
ISSN: 0870-2551
Indexing
Publicação em ISI Web of Science ISI Web of Science
Pubmed / Medline
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
CORDIS: Health sciences
Other information
Authenticus ID: P-006-BAK
Abstract (EN): Cardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocardial ischemia. For several decades, cancer therapy-induced cardiomyopathy was almost exclusively associated with the use of cumulative doses of anthracyclines, which cause permanent damage at the cellular level. However, new therapeutic agents, such as the monoclonal antibody trastuzumab, induce transient reversible myocyte dysfunction which is unrelated to the dose used. Early identification of potential cardiovascular injury, accurate diagnosis of cardiotoxic events and implementation of appropriate monitoring plans are essential in patients with cancer. Close cooperation between cardiologists and oncologists is thus crucial, in order to balance the risks and benefits of cardiotoxic anticancer therapy. In this article we review the various responses to cardiotoxic cancer treatments and their relationship with the main antineoplastic drugs used in clinical practice. In addition, we discuss the main guidelines on detection and monitoring of cardiotoxicity in patients with cancer.
Language: Portuguese
Type (Professor's evaluation): Scientific
Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=:000321596800006">Indexado na ISI Web of Science</a>
No. of pages: 15
License type: Click to view license CC BY-NC
Documents
File name Description Size
Adão, RPC, 2013 versão inglesa 739.29 KB
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