Synthesis and evaluation of antioxidant and trypanocidal properties of a selected series of coumarin derivatives

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Guíñez, RF (Author) Other; Matos, MJ (Author) Other; Vazquez Rodriguez, S (Author) Other; Santana, L (Author) Other; Uriarte, E (Author) Other; Olea Azar, C (Author) Other; Maya, JD (Author) Other

Journal

Title: Future Medicinal Chemistry

Vol. 5

Pages: 1911-1922

ISSN: 1756-8919

Publisher: Future Medicine Ltd.

Indexing

Scopus - 19 Citations

Other information

Authenticus ID: P-00R-0N7

DOI: 10.4155/fmc.13.147

Abstract (EN): This article describes the preparation and characterization of a selected series of coumarin derivatives with the aim of evaluating their antioxidant properties and their activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. All the derivatives demonstrated moderate trypanocidal activity in the epimastigote and trypomastigote stages (clone Dm28c), with Compound 3 presenting the highest trypanocidal activity of the entireseries, displaying higher activity than nifurtimox, which was used as a reference compound. In addition to the trypanocidal activity, this compound proved to have a very interesting antioxidant profile, as well as no cytotoxicity. These preliminary findings encouraged the authors to study the future structural optimization of this scaffold. © 2013 Future Science Ltd.

Language: English

Type (Professor's evaluation): Scientific