Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Pintalhão M (Author) FMUP; Maia Rocha, C (Author) Other; Castro-Chaves P (Author) FMUP; Adão, R (Author) FMUP; Barros, AS (Author) FMUP; Clara Martins, R (Author) FMUP; Leite-Moreira AF (Author) FMUP; Bettencourt, P (Author) Other; Brás-Silva C (Author) FMUP

Journal

Title: Current Problems in Cardiology

ISSN: 0146-2806

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00T-PY1

DOI: 10.1016/j.cpcardiol.2021.100860

Abstract (EN): Urocortin (Ucn)-2 has shown promising therapeutic effects on heart failure (HF). However, there are still significant knowledge gaps regarding the role and modulation of the endogenous Ucn-2 axis in the cardiovascular system and, specifically, in acute HF. We evaluated Ucn-2 levels in admission serum samples of 80 acute HF patients and assessed their association with clinical, analytical and echocardiographic parameters. Median age was 76.5 years, and 37 patients (46%) were male. Median serum Ucn-2 was 2.3ng/mL. Ucn-2 levels were positively associated with peripheral edemas (P = 0.022), hepatomegaly (P = 0.007) and sodium retention score (¿ = 0.37, P = 0.001) and inversely correlated with inferior vena cava collapse at inspiration (¿ = -0.37, P = 0.001). Additionally, patients with higher Ucn-2 levels had a higher prevalence of right atrial dilation (P = 0.027), right ventricle dilation (P = 0.008), and higher systolic pulmonary artery pressure (¿ = 0.34, P = 0.002). Regarding analytical parameters, Ucn-2 correlated positively with log BNP (r = 0.22, P = 0.055) and inversely with uric acid (r = 0.24, P = 0.029) and total (r = -0.30, P = 0.007) and low-density lipoprotein cholesterol (r = -0.23, P = 0.038). No associations were found between Ucn-2 and age, sex or left heart structure or function. In conclusion, Circulating Ucn-2 was associated with clinical and echocardiographic markers of volume overload and pulmonary hypertension in acute HF patients. © 2021 Elsevier Inc.

Language: English

Type (Professor's evaluation): Scientific