Comparative context analysis of codon pairs on an ORFeome scale

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Moura, G (Author) Other; Pinheiro, M (Author) Other; Raquel M Silva (Author) Other; miranda, im (Author) Other; Afreixo, V (Author) Other; Dias, G (Author) Other; Freitas, A (Author) Other; Oliveira, JL (Author) Other; Santos, MAS (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: ACM International Conference Proceeding Series

Vol. 6

Final page: R28

Publisher: Association for Computing Machinery

Indexing

ISI Web of Knowledge - 72 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-000-5S7

DOI: 10.1186/gb-2005-6-3-r28

Abstract (EN): Codon context is an important feature of gene primary structure that modulates mRNA decoding accuracy. We have developed an analytical software package and a graphical interface for comparative codon context analysis of all the open reading frames in a genome (the ORFeome). Using the complete ORFeome sequences of Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans and Escherichia coli, we show that this methodology permits large-scale codon context comparisons and provides new insight on the rules that govern the evolution of codon-pair context.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14