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Melanocortin signalling in fat cells

Title
Melanocortin signalling in fat cells
Type
Article in National Scientific Journal
Year
2009
Authors
Rodrigues, Adriana
(Author)
FCNAUP
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Almeida, Henrique
(Author)
FCNAUP
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Gouveia, Alexandra
(Author)
FCNAUP
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Journal
Vol. 4 No. 2
Pages: 152-152
ISSN: 1646-3439
Scientific classification
FOS: Medical and Health sciences > Other medical sciences
CORDIS: Health sciences
Other information
Resumo (PT): [resumo]
Abstract (EN): Melanocortin peptides and their receptors have long been known to affect the central control of food intake and body weight, thus playing a critical role in the development of obesity [1]. The melanocortin 5 receptor (MC5R) has been directly linked with lipid metabolism in peripheral tissues: MC5R deletion in mouse generates defects in sebaceous gland secretion [1] and MC5R stimulation increases fatty acid oxidation in muscle cells [2]. In this study, we tackled the role of MC5R in lipolysis and adipocyte function using the well established model of differentiated mouse 3T3-L1 adipocytes. Cell-signalling based experiments were performed after adipocyte treatment with alpha-melanocyte-stimulating hormone (alpha-MSH) and compared with the MC5R specific activation previously described in HEK293 [3] and HeLa cells stably transfected with MC5R-GFP. Adipocyte response to alpha-MSH resulted in a loss of cytoplasmatic lipid content and release of glycerol into the cell medium by an ERK1/2 dependent mechanism. Moreover, downstream of ERK1/2, alpha-MSH induces p90RSK and CREB phosphorylation and c-Fos expression. The correlation between alpha-MSH action in 3T3-L1 adipocytes and the specific signalling pathways underlying MC5R activation, strongly suggests that lipolysis is mediated by this receptor. [1] Cone RD (2006) Endocr Rev 27(7):736:49 [2] An et al (2007) J Biol Chem 282(5):2862-70 [3] Rodrigues et al (2009) Mol Cell Endocrinol 303:74-81
Language: English
Type (Professor's evaluation): Scientific
Contact: agouveia@med.up.pt
License type: Click to view license CC BY-NC
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