Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Monti, S (Author) Other; Craven, A (Author) Other; Klersy, C (Author) Other; Montecucco, C (Author) Other; Caporali, R (Author) Other; Watts, R (Author) Other; Merkel, PA (Author) Other; Luqmani, R (Author) Other; Achilleos, K (Author) Other; Adler, M (Author) Other; Alba, MA (Author) Other; Alba, MA (Author) Other; Albert, DA (Author) Other; Alibaz-Oner, F (Author) Other; Allcoat, P (Author) Other; Amano, K (Author) Other; Amarasuriya, M (Author) Other; Amudala, NA (Author) Other; Andrews, J (Author) Other; Archer, AM (Author) Other; Arimura, Y (Author) Other; Atukorala, I (Author) Other; Elsa Azevedo (Author) FMUP; Bajad, S (Author) Other; Baldwin, C (Author) Other; Barra, LJ (Author) Other; Baslund, B (Author) Other; Basu, N (Author) Other; Baykal, M (Author) Other; Berger, C (Author) Other; Berglin, E (Author) Other; Besada, E (Author) Other; Bhardwaj, M (Author) Other; Bischof, A (Author) Other; Blockmans, D (Author) Other; Blood, J (Author) Other; Draibe, JB (Author) Other; Brand, S (Author) Other; Brandao, M (Author) Other; Bruce, IN (Author) Other; Butler, A (Author) Other; Calabrese, LH (Author) Other; Ferrer, DC (Author) Other; Carette, S (Author) Other; Carmona, D (Author) Other; Ceunen, H (Author) Other; Chakravarty, K (Author) Other; Chapman, PT (Author) Other; Chocova, Z (Author) Other; Chung, SA (Author) Other; Ci, W (Author) Other; Cid, MC (Author) Other; Clark, TM (Author) Other; Clarkson, MR (Author) Other; de Jesus Contreras-Rodríguez, F (Author) Other; Conway, R (Author) Other; Cooke, K (Author) Other; Virós, XC (Author) Other; Cordeiro, A (Author) Other; Costa, A (Author) Other; Craven, A (Author) Other; Culfear, K (Author) Other; Daikeler, T (Author) Other; Danda, D (Author) Other; Das, SK (Author) Other; Dasgupta, B (Author) Other; De Castro, AM (Author) Other; Dehghan, N (Author) Other; Devassy, R (Author) Other; Dhindsa, N (Author) Other; Diamantopoulos, AP (Author) Other; Direskeneli, H (Author) Other; Dobashi, H (Author) Other; Juan, D (Author) Other; Durrani, M (Author) Other; Edelsten, C (Author) Other; Eifert, J (Author) Other; Elhayek, S (Author) Other; Elsideeg, S (Author) Other; Endo, T (Author) Other; Erden, A (Author) Other; Erer, B (Author) Other; Eriksson, P (Author) Other; Erturk, Z (Author) Other; Espígol-Frigolé, G (Author) Other; Felicetti, M (Author) Other; Ferraro, A (Author) Other; Ferro, JM (Author) Other; Fifi-Mah, A (Author) Other; Flores-Suárez, LF (Author) Other; Flossmann, O (Author) Other; Flynn, D (Author) Other; Fonseca, JE (Author) Other; Foot, J (Author) Other; Foote, M (Author) Other; Forbess, L (Author) Other; Fujimoto, S (Author) Other; Fukuoka, K (Author) Other; Furtado, C (Author) Other; Furuta, S (Author) Other; Gaffo, AL (Author) Other; Gallagher, P (Author) Other; Gao, N (Author) Other; Gatenby, P (Author) Other; Gendi, N (Author) Other; Geraldes, R (Author) Other; Gerits, A (Author) Other; Gioffredi, A (Author) Other; Gomples, L (Author) Other; Gonçalves, MJ (Author) Other; Gondo, P (Author) Other; Graham, A (Author) Other; Grainger, R (Author) Other; Gray, DT (Author) Other; Grayson, PC (Author) Other; Griffiths, L (Author) Other; Guo, Y (Author) Other; Gupta, R (Author) Other; Gylling, M (Author) Other; Hajj-Ali, RA (Author) Other; Hammam, N (Author) Other; Harigai, M (Author) Other; Hartley, L (Author) Other; Haslett, J (Author) Other; Hassan, A (Author) Other; Hatemi, G (Author) Other; Hellmich, B (Author) Other; Henckaerts, L (Author) Other; Henes, JC (Author) Other; Hepburn, J (Author) Other; Herd, V (Author) Other; Hess, C (Author) Other; Hill, C (Author) Other; Hinojosa-Azaola, A (Author) Other; Hirahashi, J (Author) Other; Hirano, F (Author) Other; Ho¿evar, A (Author) Other; Holle, J (Author) Other; Hollinger, N (Author) Other; Homma, S (Author) Other; Howard, T (Author) Other; Hoyles, RK (Author) Other; Hruskova, Z (Author) Other; Hutcheon, G (Author) Other; Ignacak, M (Author) Other; Igney-Oertel, A (Author) Other; Ikeda, K (Author) Other; Ikegaya, N (Author) Other; Jagadeesh, S (Author) Other; Jaquith, J (Author) Other; Jayne, DRW (Author) Other; Jewell, T (Author) Other; Jones, C (Author) Other; Joshi, A (Author) Other; Kalyoncu, U (Author) Other; Kamal¿, S (Author) Other; Kamath, S (Author) Other; Lai, KS (Author) Other; Kaname, S (Author) Other; Kanchinadham, S (Author) Other; Karada¿, Ö (Author) Other; Karube, M (Author) Other; Kaszuba, M (Author) Other; Kaur, R (Author) Other; Kawakami, T (Author) Other; Kawashima, S (Author) Other; Khalidi, N (Author) Other; Khan, A (Author) Other; Kikuchi, M (Author) Other; Kilic, L (Author) Other; Kimura, M (Author) Other; King, MJ (Author) Other; Klapa, S (Author) Other; Klocke, R (Author) Other; Kobayashi, T (Author) Other; Kobayashi, S (Author) Other; Komagata, Y (Author) Other; Kronbichler, A (Author) Other; Kuczia, P (Author) Other; Kumar, MS (Author) Other; Kurosawa, M (Author) Other; Lamprecht, P (Author) Other; Langford, CA (Author) Other; Lanyon, P (Author) Other; Laversuch, C (Author) Other; Lee, SJ (Author) Other; Leoni, S (Author) Other; Li, J (Author) Other; Liang, K (Author) Other; Liang, P (Author) Other; Liao, H (Author) Other; Lee, LA (Author) Other; Luqmani, RA (Author) Other; Lyle, A (Author) Other; MacDonald, M (Author) Other; Mackie, SL (Author) Other; Madden, L (Author) Other; Magliano, M (Author) Other; Makino, H (Author) Other; Makol, A (Author) Other; Malaiya, R (Author) Other; Malaviya, A (Author) Other; Manthri, R (Author) Other; Maritati, F (Author) Other; da Silva, AM (Author) Other; Mason, JC (Author) Other; Matara, C (Author) Other; Matsui, K (Author) Other; Matteson, EL (Author) Other; McBride, D (Author) Other; McCullough, K (Author) Other; McGeoch, L (Author) Other; McLaren, J (Author) Other; McMillian, C (Author) Other; Mendiratta, N (Author) Other; Menon, A (Author) Other; Merinopoulos, D (Author) Other; Merkel, PA (Author) Other; Merkel, P (Author) Other; Messier, S (Author) Other; Micheletti, RG (Author) Other; Mills, K (Author) Other; Milman, N (Author) Other; Minoda, M (Author) Other; Minz, RW (Author) Other; Möck, C (Author) Other; Mohammad, AJ (Author) Other; Moiseev, S (Author) Other; Moitinho, M (Author) Other; Molloy, E (Author) Other; Monach, PA (Author) Other; Montgomery, M (Author) Other; Moosig, F (Author) Other; Moradizadeh, M (Author) Other; Morgan, M (Author) Other; Morgan, AW (Author) Other; Morgan, A (Author) Other; Muir, A (Author) Other; Mukhtyar, C (Author) Other; Müller, A (Author) Other; Muratore, F (Author) Other; Muso, E (Author) Other; Nada, R (Author) Other; Nakajima, H (Author) Other; Nakajima, T (Author) Other; Nakano, H (Author) Other; Nandagudi, A (Author) Other; Neumann, T (Author) Other; Ng, YF (Author) Other; Ng, KH (Author) Other; Nogueira, EL (Author) Other; Nolkha, N (Author) Other; Nordström, D (Author) Other; Novikov, P (Author) Other; Nugaliyadde, A (Author) Other; O¿Donnell, JL (Author) Other; O¿Donoghue, J (Author) Other; O¿Neill, L (Author) Other; O¿Riordan, E (Author) Other; Oatley, M (Author) Other; Okubo, K (Author) Other; Oliva, E (Author) Other; Oshikawa, H (Author) Other; Ota, Y (Author) Other; Padoan, R (Author) Other; Pagnoux, C (Author) Other; Pan, L (Author) Other; Panaritis, K (Author) Other; Park, JK (Author) Other; Patel, S (Author) Other; Patil, P (Author) Other; Pazzola, G (Author) Other; Peall, A (Author) Other; Pearce, F (Author) Other; Pehlevan, S (Author) Other; Pereira, L (Author) Other; Pettersson, T (Author) Other; Pineau, CA (Author) Other; Pirilä, L (Author) Other; Poglodek, B (Author) Other; Ponte, C (Author) Other; Prieto-González, S (Author) Other; Priya, SR (Author) Other; Purewal, B (Author) Other; Purschke, S (Author) Other; Putaala, J (Author) Other; Quickert, S (Author) Other; Quincey, V (Author) Other; Raghuvanshi, S (Author) Other; Rajasekhar, L (Author) Other; Ranganathan, D (Author) Other; Rathi, M (Author) Other; Rees, D (Author) Other; Rees, F (Author) Other; Renken, U (Author) Other; Restuccia, G (Author) Other; Rhee, RL (Author) Other; Rice, B (Author) Other; Robins, D (Author) Other; Robson, J (Author) Other; Robson, J (Author) Other; Rodrigues, M (Author) Other; Romão, VC (Author) Other; Rotar, ´ (Author) Other; Ruediger, C (Author) Other; Rutgers, A (Author) Other; Sá, AC (Author) Other; Saavedra, MJ (Author) Other; Sada, K (Author) Other; Sahbudin, I (Author) Other; Salvarani, C (Author) Other; Sandhu, N (Author) Other; Santos, E (Author) Other; Sato, Y (Author) Other; Schäfer, VS (Author) Other; Schiavon, F (Author) Other; Schmidt, WA (Author) Other; Segelmark, M (Author) Other; Shahin, A (Author) Other; Sharma, A (Author) Other; Shotton, J (Author) Other; Silva, C (Author) Other; Singer, OG (Author) Other; Sivasuthan, G (Author) Other; Smolen, S (Author) Other; Solanich-Moreno, X (Author) Other; Boixader, LS (Author) Other; Song, YW (Author) Other; Springer, J (Author) Other; Sreih, AG (Author) Other; Sreih, AG (Author) Other; Srivastava, R (Author) Other; Stamp, LK (Author) Other; Stevens, R (Author) Other; Strbian, D (Author) Other; Sugino, K (Author) Other; Sunderkötter, C (Author) Other; Suppiah, R (Author) Other; Suzuki, K (Author) Other; Suzuki, K (Author) Other; Szekanecz, Z (Author) Other; Sznajd, J (Author) Other; Taimen, K (Author) Other; Tak, PP (Author) Other; Takeuchi, T (Author) Other; Takizawa, N (Author) Other; Tames, L (Author) Other; Tan, BE (Author) Other; Tanaka, M (Author) Other; Tang, MW (Author) Other; Tatlisumak, T (Author) Other; Tesar, V (Author) Other; Thomas, A (Author) Other; Tian, X (Author) Other; Tokunaga, K (Author) Other; Tombetti, E (Author) Other; Tom¨i¿, M (Author) Other; Toz, B (Author) Other; Tsukamoto, T (Author) Other; Uchida, S (Author) Other; Unal, AU (Author) Other; Urban, ML (Author) Other; Usui, J (Author) Other; Vaglio, A (Author) Other; Venkatachalam, S (Author) Other; Vermaak, E (Author) Other; Viswanath, V (Author) Other; Wada, T (Author) Other; Wagh, S (Author) Other; Wallace, DJ (Author) Other; Walters, G (Author) Other; Walz, B (Author) Other; Wan, J (Author) Other; Wang, T (Author) Other; Wang, G (Author) Other; Warrington, KJ (Author) Other; Watts, RA (Author) Other; Wawrzycka-Adamczyk, K (Author) Other; Weeratunga, P (Author) Other; Weisman, MH (Author) Other; Wickramasinghe, S (Author) Other; Williams, M (Author) Other; Williams, M (Author) Other; Wojcik, K (Author) Other; Woodruff, L (Author) Other; Xenitidis, T (Author) Other; Yamada, H (Author) Other; Yamagata, K (Author) Other; Yee, C (Author) Other; Yoon, M (Author) Other; Yoshida, K (Author) Other; Yoshifuji, H (Author) Other; Ytterberg, SR (Author) Other; Yumura, W (Author) Other; Zayed, H (Author) Other; Zeng, X (Author) Other; Zhao, M (Author) Other; Zugaj, A (Author) Other; Zuk, J (Author) Other

Journal

Title: Rheumatology

Vol. 60

Pages: 617-628

ISSN: 1462-0324

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 25 Citations

Other information

Authenticus ID: P-00T-WVH

DOI: 10.1093/rheumatology/keaa215

Abstract (EN): Objectives. ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods. We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65years or >= 65years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results. A total of 1338 patients with AAV were included: 66% had disease onset at <65years of age [female 50%; mean age 48.4years (S.D. 12.6)] and 34% had disease onset at >= 65years [female 54%; mean age 73.6years (S.D. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0 .001) . Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6month VDI >= 5, compared with 7% of younger patients (P = 0 .01) . Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0 .03]. Conclusion. Within 6 months of diagnosis of AAV, patients >65years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 12