Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Pedro Castro (Author) FMUP; Serrador, J (Author) Other; Rocha, I (Author) Other; Castro-Chaves P (Author) FMUP; Sorond, F (Author) Other; Elsa Azevedo (Author) FMUP

Journal

Title: Journal of Thrombosis and Thrombolysis

Vol. 50

Pages: 753-761

ISSN: 0929-5305

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00S-8TD

DOI: 10.1007/s11239-020-02166-9

Abstract (EN): The cerebrovascular effects of a failing heart-pump are largely unknown. Chronic heart failure (HF) might cause pre-conditioning effect on cerebral hemodynamics but not study so far in acute stroke. We aimed to investigate if HF induces effects in dynamic cerebral autoregulation (CA), within 6 h of symptom-onset through chronic stage of ischemic stroke. We enrolled 50 patients with acute ischemic stroke. Groups with (N = 8) and without HF and 20 heathy controls were compared. Arterial blood pressure (Finometer) and cerebral blood flow velocity (transcranial Doppler) were monitored within 6 and at 24 h from symptom-onset and at 3 months. We assessed dynamic CA by transfer function analysis and cardiac disease markers. HF associated with higher phase (better dynamic CA) at ischemic hemisphere within 6 (p = 0.042) and at 24 h (p = 0.006) but this effect was not evident at 3 months (p > 0.05). Gain and coherence trends were similar between groups. We found a positive correlation between phase and admission troponin I levels (Spearman's r = 0.348, p = 0.044). Our findings advances on the knowledge of how brain and heart interact in acute ischemic stroke by showing a sustained dynamic cerebral autoregulation response in HF patients mainly with severe aortic valve disease. Understanding the physiological mechanisms that govern this complex interplay can be useful to find novel therapeutic targets which can improve outcome in ischemic stroke.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9