Evaluation of Cerebral Microvascular Regulatory Mechanisms with Transcranial Doppler in Fabry Disease

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Pedro Castro (Author) FMUP; Gutierres, M (Author) Other; Pereira, G (Author) Other; Ferreira, S (Author) FMUP; João Paulo Oliveira (Author) FMUP; Elsa Azevedo (Author) FMUP

Journal

Title: Brain Sciences

Vol. 10 No. 8, Article number 556

Pages: 1-9

ISSN: 2076-3425

Publisher: MDPI

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00S-JHS

DOI: 10.3390/brainsci10080528

Abstract (EN): Background: Fabry disease (FD) causes cerebrovascular disease (CVD) even if asymptomatic, and this is why it is important to identify non-invasive methods to monitor the disease. We evaluated the usefulness of the cerebral autoregulation, vasoreactivity, and neurovascular coupling assessed by transcranial Doppler (TCD) in FD. Methods: Ten adult patients with classic phenotype FD, without clinical expression of CVD, and ten healthy controls, were included. We monitored cerebral blood flow velocity with TCD in the middle and posterior cerebral arteries, blood pressure, heart rate, and non-invasive expired carbon dioxide (CO2). Cerebral autoregulation was calculated from the spontaneous oscillations of blood pressure, cerebral vasoreactivity through CO(2)inhalation and hyperventilation and neurovascular coupling by the flow velocity change to visual stimulation. Results: FD male patients showed blunted vasoreactivity in posterior circulation (0.70 +/- 0.36%/mmHg vs. 1.09 +/- 0.18%/mmHg CO2,p= 0.01) and impaired neurovascular coupling (overshoot 15 +/- 2.9% vs. 28 +/- 6.1%,p< 0.01). Cerebral autoregulation was similar to controls. Conclusion: Male patients with FD classic phenotype and hitherto clinical expression of CVD already show impairment of cerebral vasoreactivity and neurovascular coupling. It supports the notion of an early dysfunction of cerebral microvascular in a presymptomatic stage of CVD in FD and that TCD could be useful in its assessment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9