TRP channels in the urinary bladder and prostate: implications for therapy.

• Type: Chapter or Part of a Book
• Date: 2011

Authors

Charrua, Ana (Author) FCNAUP; Cruz, F. (Author) Other

Book

Title: TRP channels in health and disease: implications for diagnosis and therapy.

Pages: 243-258

Indexing

Scopus - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Urology

Other information

Authenticus ID: P-00Q-5YD

Resumo (PT): In the last two decades, major advances have been made on TRPV1 expression and function in the urinary bladder. Much of this was accomplished after the cloning of the TRPV1 receptor. The development of antibodies against TRPV1 allowed the study of the receptor distribution. Moreover, the raise of transgenic mice lacking TRPV1 gene and the discovery and development of molecules that modulate the receptor brought new insights on TRPV1‘s important role in the occurrence of urinary bladder pathologies. More recently, effective TRPV1 antagonists were developed and tested with success in intact bladders and in several models of bladder disease, further disclosing the role of TRPV1 in micturition dysfunction. The easy access to TRPV1 receptors in the human urinary bladder to desensitizing vanilloids agents, like capsaicin and resiniferatoxin, represents one of the first successful therapeutic approaches based in TRPV1 receptor modulation.

Abstract (EN): In the last two decades, major advances have been made on TRPV1 expression and function in the urinary bladder. Much of this was accomplished after the cloning of the TRPV1 receptor. The development of antibodies against TRPV1 allowed the study of the receptor distribution. Moreover, the raise of transgenic mice lacking TRPV1 gene and the discovery and development of molecules that modulate the receptor brought new insights on TRPV1‘s important role in the occurrence of urinary bladder pathologies. More recently, effective TRPV1 antagonists were developed and tested with success in intact bladders and in several models of bladder disease, further disclosing the role of TRPV1 in micturition dysfunction. The easy access to TRPV1 receptors in the human urinary bladder to desensitizing vanilloids agents, like capsaicin and resiniferatoxin, represents one of the first successful therapeutic approaches based in TRPV1 receptor modulation.

Language: English

Type (Professor's evaluation): Scientific