Caspase-3 and bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Henrique Almeida (Author) FMUP; Liliana Matos (Author) FCNAUP; Delminda Neves (Author) FMUP

Journal

Title: Annals of the New York Academy of Sciences

Vol. 1119

Pages: 190-195

ISSN: 0077-8923

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 1 Citation

ISI Web of Science

Scopus - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences > Medical sciences > Medicine > Endocrinology ; Natural sciences > Biological sciences > Biology > Cell biology

Other information

Authenticus ID: P-004-DYW

DOI: 10.1196/annals.1404.021

Abstract (EN): Adrenocortical cell death by apoptosis is a common finding when adrenocorticotropic hormone is suppressed. Despite the well-known final structural features exhibited by those cells, data on the mechanisms preceding these final events are lacking. In this study, after 3 days of dexamethasone administration to rats of different ages, rat adrenals were processed for immunocytochemical study. In the zona reticularis, there was evidence of the activation of Bcl-2 and caspase-3 proteins. Beyond a small age-related increase in labeled cells, the number of cells presenting colocalization for both proteins was noteworthy. The results confirm the involvement of Bcl-2 and caspase-3 proteins in the apoptotic pathway and suggest their simultaneous intervention.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6