Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Amaral, R (Author) FMUP; Jacome, C (Author) FMUP; Almeida, R (Author) FMUP; Pereira, AM (Author) FMUP; Alves Correia, M (Author) Other; Mendes, S (Author) Other; Rodrigues, JCC (Author) Other; Carvalho, J (Author) Other; Araujo, L (Author) FMUP; Costa, A (Author) Other; Silva, A (Author) Other; Teixeira, MF (Author) Other; Ferreira Magalhaes, M (Author) Other; Alves, RR (Author) Other; Moreira, AS (Author) Other; Fernandes, RM (Author) Other; Ferreira, R (Author) Other; Pinto, PL (Author) Other; Neuparth, N (Author) Other; Bordalo, D (Author) FMUP; Bom, AT (Author) Other; Calix, MJ (Author) Other; Ferreira, T (Author) Other; Gomes, J (Author) Other; Vidal, C (Author) Other; Mendes, A (Author) Other; Vasconcelos, MJ (Author) Other; Silva, PM (Author) Other; Ferraz, J (Author) Other; Morete, A (Author) Other; Pinto, CS (Author) Other; Santos, N (Author) Other; Loureiro, CC (Author) Other; Arrobas, A (Author) Other; Marques, ML (Author) Other; Lozoya, C (Author) Other; Lopes, C (Author) FMUP; Cardia, F (Author) Other; Loureiro, CC (Author) Other; Camara, R (Author) Other; Vieira, I (Author) Other; da Silva, S (Author) Other; Silva, E (Author) Other; Rodrigues, N (Author) Other; Fonseca, J (Author) FMUP

Journal

Title: International Journal of Environmental Research and Public Health

Vol. 18 No. 5

Pages: 1-11

ISSN: 1661-7827

Publisher: MDPI

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00T-BS6

DOI: 10.3390/ijerph18031015

Abstract (EN): We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11