Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Araújo JR (Author) FMUP; Gonçalves P (Author) FMUP; Martel, F (Author) FMUP

Journal

Title: Nutrition Research

Vol. 31

Pages: 77-87

ISSN: 0271-5317

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 243 Citations

Scopus - 284 Citations

Other information

Authenticus ID: P-002-VPR

DOI: 10.1016/j.nutres.2011.01.006

Abstract (EN): Colorectal cancer (CRC) is the second most fatal and the third most diagnosed type of cancer worldwide. Despite having multifactorial causes, most CRC cases are mainly determined by dietary factors. In recent years, a large number of studies have attributed a protective effect to polyphenols and foods containing these compounds (fruits and vegetables) against CRC. Indeed, polyphenols have been reported to interfere with cancer initiation, promotion, and progression, acting as chemopreventive agents. The aim of this review is to summarize the main chemopreventive properties of some polyphenols (quercetin, rutin, myricetin, chrysin, epigallocatechin-3-gallate, epicatechin, catechin, resveratrol, and xanthohumol) against CRC, observed in cell culture models. From the data reviewed in this article, it can be concluded that these compounds inhibit cell growth, by inducing cell cycle arrest and/or apoptosis; inhibit proliferation, angiogenesis, and/or metastasis; and exhibit anti-inflammatory and/or antioxidant effects. In turn, these effects involve multiple molecular and biochemical mechanisms of action, which are still not completely characterized. Thus, caution is mandatory when attempting to extrapolate the observations obtained in CRC cell line studies to humans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11