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The effect of high glucose on SERT, the human plasmalemmal serotonin transporter

Title
The effect of high glucose on SERT, the human plasmalemmal serotonin transporter
Type
Article in International Scientific Journal
Year
2008
Authors
Gonçalves P
(Author)
FMUP
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Martel, F
(Author)
FMUP
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Journal
Vol. 11
Pages: 244-250
ISSN: 1028-415X
Publisher: Taylor & Francis
Other information
Authenticus ID: P-003-TPS
Abstract (EN): The aim of this work was to investigate the effect of short- and long-term high-glucose exposure on the plasmalemmal serotonin transporter (SERT)-mediated uptake of [(3)H]-serotonin (5-HT) by Caco-2 cells. Short-term exposure of Caco-2 cells to high apical glucose levels (30 mM for 2 h or 40 mM for 1 h) decreased the uptake of [(3)H]-5-HT by 20-30%. On the other hand, long-term (21-24 weeks) exposure of the cells to high (25 mM) glucose caused a 30% increase in the uptake of [(3)H]-5-HT. Under these conditions, the affinity of the transporter for 5-HT and noradrenaline was not significantly changed, and the inhibitory potencies of fluoxetine and desipramine were also unchanged. In conclusion, high-glucose levels modulate SERT activity. A short- term exposure of the cells to a high concentration of glucose decreases the activity of the transporter, whereas a longer exposure of the cells to a high concentration of glucose increases the activity of SERT, without interfering with its affinity.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 7
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