Intestinal fructose absorption: Modulation and relation to human diseases

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Goncalves, AS (Author) Other; Andrade, N (Author) Other; Martel, F (Author) FMUP

Journal

Title: PharmaNutrition

Vol. 14

ISSN: 2213-4344

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00T-0AR

DOI: 10.1016/j.phanu.2020.100235

Abstract (EN): Background: Fructose is a hexose sugar found naturally in our diet and excessive fructose consumption has been documented in humans over the last decades. Fructose absorption in the small intestine is a highly regulated process and GLUT5 plays an essential role in this process, but GLUT2 is also involved. Methods: In this review, we will describe the multiple mechanisms involved in the regulation of intestinal fructose absorption and the effects of excessive consumption of this sugar on human health. Results: Excessive fructose intake is associated with a growing incidence of certain diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiac disease, gastrointestinal disorders, and cancer. It is also associated with changes in gut integrity and microbiota. Conclusions: High fructose consumption is associated with the development of characteristics of metabolic syndrome and of other diseases such as cardiomyopathies, kidney disease and tumor growth, in both humans and rodents So, modulation of GLUT5and/or GLUT2-mediated intestinal fructose absorption might provide a novel pharmacologic strategy for the treatment of these diseases. However, most of the data on high fructose consumption has been obtained in rodent models, and so more studies are needed in order to fully confirm these observations in humans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9