Short-term exposure to somatostatin or muscarinic agonists regulates acetylcholine-evoked H-3-MPP+ release from bovine adrenal chromaffin cells

• Type: Article in International Conference Proceedings Book
• Date: 2007

Authors

ribeiro, l (Author) FMUP; Martel, F (Author) FMUP; Azevedo, I (Author) Other

Conference proceedings International

Title: JOINT MEETING OF THE SLOVAK PHYSIOLOGICAL SOCIETY, THE PHYSIOLOGICAL SOCIETY AND THE FEDERATION OF EUROPEAN PHYSIOLOGICAL SOCIETIES

Pages: 13-16

Joint Meeting of the Slovak-Physiological-Society/Physiological-Society/Federation-of-European-Physiological-Societies

Bratislava, SLOVAKIA, SEP 11-14, 2007

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-004-DK2

Abstract (EN): The present research examined the effect of a short-term exposure to somatostatin (SS) or to muscarinic receptor agonists upon acetylcholine (ACH)induced release of H-3-MPP+ from bovine adrenal medullary cells. Somatostatin (SS, 0.01-0.1 mu M) reproduced the effect of the muscarinic agonists, by depressing ACH-elicited H-3-MPP+ release by 25-27%, but only when a 500 mu M ACH concentration was used. The SS receptor (SSTR)2, 3 and 4 subtype agonists mimicked the effects of SS, and the SSTR non-selective antagonist counteracted its inhibitory effect. In the presence of either oxotremorine or pilocarpine the SS inhibitory effect on 500 mu M ACH-induced H-3-MPP+ release was no longer detectable. We conclude that SS and muscarinic agonists may share some signalling pathways involved in catecholamine (CA) handling.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4