Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Leite Ferreira, BJML (Author) Other; Martel, F (Author) FMUP; Silva, C (Author) Other; Santos, TM (Author) Other; Daniel da Silva, AL (Author) Other

Journal

Title: Journal of Inorganic Biochemistry

Vol. 213

ISSN: 0162-0134

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00S-VJT

DOI: 10.1016/j.jinorgbio.2020.111258

Abstract (EN): Cisplatin has demonstrated extraordinary anticancer activity against a variety of solid tumors. However, its clinical efficacy is contrasted by its toxicity profile. Having in mind the need to reduce the toxicity, promote a sustained release and enhance the body-circulation time of cisplatin, herein novel nanocarriers consisting of core-shell silica-coated iron oxide nanoparticles functionalized with dicarboxylic acid groups were prepared and characterized. Cisplatin was conjugated with the functionalized nanoparticles by surface tethering. Controlled release of cisplatin was observed without burst effect and in a sustained profile for up to 3 days. In vitro studies showed cytotoxic and antiproliferative effects of the cisplatin nanoconjugates against a human pancreatic cancer cell line. Importantly, when compared with free cisplatin, nanoconjugates exhibited lower cytotoxic effects regarding nonmalignant human duct pancreatic cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11