Development of novel Cu(I) compounds with vitamin B-1 derivative and their potential application as anticancer drugs

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Brandao, P (Author) Other; Guieu, S (Author) Other; Correia Branco, A (Author) Other; Silva, C (Author) Other; Martel, F (Author) FMUP

Journal

Title: Inorganica Chimica Acta

Vol. 487

Pages: 287-294

ISSN: 0020-1693

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00X-W66

DOI: 10.1016/j.ica.2018.12.017

Abstract (EN): The synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu-4[(mu(3)-thiocrome)(2)Cl-4]center dot 2(H2O)}(n) 1, and Cu-2[(mu(2)-thiocrome)(2)Cl-2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain structure based on the linkage of two crystallographic different copper centers and thiochrome ligand through the N(1), N (2) and N(3) nitrogen atoms. Compound 2 is a 0D dimeric copper structure assembled by two thiochrome ligands. For both compounds, the copper(I) centers exhibits a distorted trigonal pyramidal geometry. The antitumor capacity of both compounds was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability. The two compounds showed similar IC50 values, and were slightly more potent than cisplatin, against the same cell line.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8