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Oxidative stress decreases uptake of neutral amino acids in a human placental cell line (BeWo cells)

Title
Oxidative stress decreases uptake of neutral amino acids in a human placental cell line (BeWo cells)
Type
Article in International Scientific Journal
Year
2013
Authors
Correia Branco, A
(Author)
Other
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Pereira, AC
(Author)
Other
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Maria João Pinho
(Author)
FMUP
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Elisa Keating
(Author)
FMUP
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Martel, F
(Author)
FMUP
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Journal
Vol. 40
Pages: 76-81
ISSN: 0890-6238
Publisher: Elsevier
Other information
Authenticus ID: P-006-7ZD
Abstract (EN): Increased oxidative stress (OS) is implicated in the pathophysiology of several pregnancy disorders. We aimed to investigate the effect of tert-butylhydroperoxide (TBHP)-induced OS upon the placental transport of the neutral amino acids L-methionine (L-Met) and L-alanine (L-Ala), by using a human trophoblast cell model (BeWo cells). TBHP reduced both total and Ne-independent C-14-L-Met intracellular steady-state accumulation over time (A(max)), by reducing non-system L-mediated uptake - most probably system y(+) while having no effect on system L. Moreover, TBHP reduced total C-14-L-Ala A(max) through an inhibition of system A. The effect of TBHP upon total, but not system A-mediated, C-14-L-Ala uptake was dependent upon phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) activation, and was completely prevented by the polyphenol quercetin. In conclusion, a reduction in placental uptake of neutral amino acids may contribute to the deleterious effects of pregnancy disorders associated with OS.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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