Follicular lesions with papillary nuclear characteristics: differences in chromatin detected by computerized image analysis

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Coelho, BP (Author) Other; Valentim, FD (Author) Other; Miot, HA (Author) Other; Jaune, DTA (Author) Other; Hayashi, CY (Author) Other; de Oliveira, CC (Author) Other; Marques, MD (Author) Other; Tagliarini, JV (Author) Other; Castilho, EC (Author) Other; Soares, P (Author) FMUP; Mazeto, GMFD (Author) Other

Journal

Title: Archives of endocrinology and metabolism

Vol. 64

Pages: 630-635

ISSN: 2359-3997

Publisher: Segmento Farma Editores

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00S-X1T

DOI: 10.20945/2359-3997000000282

Abstract (EN): Objective: Follicular lesions of the thyroid with papillary carcinoma nuclear characteristics are classified as infiltrative follicularvariant of papillary thyroid carcinoma-FVPTC (IFVPTC), encapsulated/ well demarcated FVPTC with tumour capsular invasion (IEFVPTC), and the newly described category "non-invasive follicularthyroid neoplasm with papillary-like nuclear features" (NIFTP) formerly known as non-invasive encapsulated FVPTC.This study evaluated whether computerized image analysis can detect nuclear differences between these three tumour subtypes. Materials and methods: Slides with histological material from 15 cases of NIFTP and 33 cases of FVPTC subtypes (22 IEFVPTC, and 11 IFVPTC) were analyzed using the Image J image processing program.Tumour cells were compared for both nuclear morphometry and chromatin textural characteristics. Hestia:, Nuclei from NIFTP and IFVPTC tumours differed in terms of chromatin textural features (grey intensity): mean (92.37 +/- 21.01 vs 72.99 +/- 14.73, p = 0.02), median (84.93 +/- 21.17 vs 65.18 +/- 17.08, p = 0.02), standard deviation (47.77 +/- 9.55 vs 39.39 +/- 7.18; p = 0.02), and coefficient of variation of standard deviation (19.96 +/- 4.01 vs 24.75 +/- 3.31; p = 0.003). No differences were found in relation to IEFVPTC. Conclusion. Computerized image analysis revealed differences in nuclear texture between NIFTP and IFVPTC, but not for IEFVPTC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6