Epstein-Barr virus gene expression and latency pattern in gastric carcinomas: a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Ribeiro, J (Author) Other; Oliveira, C (Author) ICBAS; Malta, M (Author) Other; Sousa, H (Author) Other

Journal

Title: Future Oncology

Vol. 13

Pages: 567-579

ISSN: 1479-6694

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00M-F9Z

DOI: 10.2217/fon-2016-0475

Abstract (EN): Methods: A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC). Results: The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases. Conclusion: EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13