Long-Term Effect of Anti-VEGF Agents on Ilntraocullar Pressure on Age-Rellated Macular Degeneration

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Beato, J (Author) FMUP; Pedrosa, AC (Author) Other; Pinheiro Costa, J (Author) Other; Freitas da Costa, P (Author) Other; Manuel Falcão (Author) FMUP; Melo, A (Author) Other; Estrela Silva, S (Author) Other; Falcão-Reis F (Author) FMUP; Ângela Carneiro (Author) FMUP

Journal

Title: Ophthalmic Research

Vol. 56

Pages: 30-34

ISSN: 0030-3747

Publisher: Karger

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00M-WWT

DOI: 10.1159/000444395

Abstract (EN): Purpose: To analyze the effect of anti-vascular endothelial growth factor (VEGF) agents on intraocular pressure (IOP) in patients with neovascular age-related macular degeneration (AMD). Materials and Methods: This is a retrospective study that included 72 patients treated unilaterally with anti-VEGF agents according to a pro re nata regimen. Fellow non injected eyes (n = 72) were used as controls. IOP variation and the development of sustained ocular hypertension (OHT) were assessed both in the injected and in the fellow eyes. Results: While the final IOP was not significantly different between the 2 groups, sustained OHT developed in 4.2% of the injected eyes and 1.4% of the controls. In the study group, no significant IOP variation was noted during follow-up in patients receiving 20 injections, but there was a significant increase in IOP with time in more frequently treated patients (p = 0.041). Comparison of both subgroups demonstrated that patients receiving >20 injections suffered significantly greater IOP variation (p = 0.034) during follow-up, and that these patients tended to require IOP-lowering treatment more frequently (p = 0.090). Conclusion: Multiple anti-VEGF injections lead to an increase in IOP, although this variation is not sufficient to cause development of OHT in the majority of patients. (C) 2016 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5