Silodosin: a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Osman, NI (Author) Other; Chapple, CR (Author) Other; Francisco Cruz (Author) FMUP; Desgrandchamps, F (Author) Other; Llorente, C (Author) Other; Montorsi, F (Author) Other

Journal

Title: Expert Opinion on Pharmacotherapy

Vol. 13

Pages: 2085-2096

ISSN: 1465-6566

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-002-57D

DOI: 10.1517/14656566.2012.714368

Abstract (EN): Introduction: Silodosin is a new uroselective alpha-blocker with high pharmacological selectivity for the (1A) adrenoceptor. It is an effective and well-tolerated treatment in men with lower urinary tract symptoms (LUTS), due to presumed bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The efficacy of silodosin is at least equivalent to existing selective alpha-1 antagonists such as tamsulosin. A beneficial consequence of its high selectivity is improved cardiovascular safety and failure to interact with other therapies such as anti-hypertensives and phosphodiesterase type-5 inhibitors. Areas covered: This paper discusses the mechanism of action, uroselectivity and clinical efficacy/tolerability of Silodosin. Additionally, drug interactions and urodynamic effects are reviewed with a focus on ejaculatory dysfunction. Expert opinion: Silodosin is a rapidly efficacious and safe agent in the treatment of LUTS/BPH in men. A lack of clinically important cardiovascular side effects makes it of potential use in the elderly. There is a higher risk of ejaculatory dysfunction, which may lead to discontinuation in younger men. The availability of generic counterparts may make this compound less marketable in countries with social healthcare systems.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12