Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Lima, M (Author) Other; Canelhas, A (Author) Other; Santos, C (Author) Other; Teixeira, MD (Author) Other; Coutinho, J (Author) Other; Alves, R (Author) Other; Queiros, ML (Author) Other; Fonseca, S (Author) Other; Santos, AH (Author) Other; Goncalves, V (Author) Other; Massa, A (Author) Other; Justica, B (Author) Other

Journal

Title: LEUKEMIA & LYMPHOMA

Vol. 44

Pages: 525-529

ISSN: 1042-8194

Publisher: INFORMA HEALTHCARE

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-000-K3Q

DOI: 10.1080/1042819021000035626

Abstract (EN): In contrast to the majority of alphabeta peripheral T cell lymphomas (PTCL), which usually originate in lymph nodes and do not express NK-associated molecules, most gammadelta PTCL express a cytotoxic phenotype and originate at extranodal sites. We report a case of a patient with a gamma-delta PTCL who presented with large mandibular and parotidal lymphadenopathy and skin lesions. CD3(+)/TCR-Vdelta1(+) lymphoma cells did not express the cell surface (CD11b, CD11c, CD16, CD56 and CD57) and cytoplasmic granule molecules (Perforin and Granzyme B) that usually characterize the cytotoxic T-cells, a phenotype that fulfils the criteria for diagnosis of a rare non-cytotoxic variant of a gammadelta T-cell lymphoma. " In situ " hybridization for Epstein-Barr virus-encoded RNA and latent membrane protein-1 gave negative results. The disease had an aggressive course and was resistant to chemotherapy and the patient died 4 months after diagnosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5