Hematological remission and long term hematological control of acute myeloblastic leukemia induced and maintained by granulocyte-colony stimulating factor (G-CSF) therapy

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Xavier, L (Author) Other; Cunha, M (Author) Other; Goncalves, C (Author) Other; Teixeira, MD (Author) Other; Coutinho, J (Author) Other; Ribeiro, ACP (Author) Other; Lima, M (Author) Other

Journal

Title: LEUKEMIA & LYMPHOMA

Vol. 44

Pages: 2137-2142

ISSN: 1042-8194

Publisher: INFORMA HEALTHCARE

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-000-EB2

DOI: 10.1080/1042819031000111053

Abstract (EN): We describe a case of a patient with CD34+, TdT+, CD13-, CD33-, MPO- undifferentiated acute leukemia who refused chemotherapy and who achieved complete hematological remission 14 months after the diagnosis, during a short course of granulocyte-colony stimulating factor (G-CSF) for neutropenia and life threatening infection. Relapse occurred approximately one year later and G-CSF was reintroduced, being maintained for 4 months, at a dose and frequency adapted to maintain normal blood counts, a complete hematological remission being achieved again. Five months after withdrawing the G-CSF therapy a second relapse was observed; G-CSF was tried again with success, resulting in a very good hematological response that was sustained by G-CSF maintenance therapy. One year latter there was the need of increasing the doses of G-CSF in order to obtain the same hematological effect, at same time blast cells acquired a more mature CD34+, TdT-, CD13+, CD33-, MPO+ myeloid phenotype. Finally, the patient developed progressive neutropenia, anemia, thrombocytopenia and acute leukemia in spite of G-CSF therapy, dying 64 months after initial diagnosis (50 months after starting G-CSF therapy) with overt G-CSF resistant acute myeloblastic leukemia (AML), after failure of conventional induction chemotherapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6