Smoking and Helicobacter pylori infection

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Ferro, A (Author) Other; Morais, S (Author) Other; Pelucchi, C (Author) Other; Aragonés, N (Author) Other; Kogevinas, M (Author) Other; López-Carrillo, L (Author) Other; Malekzadeh, R (Author) Other; Tsugane, S (Author) Other; Hamada, GS (Author) Other; Hidaka, A (Author) Other; Hernández-Ramírez, RU (Author) Other; López-Cervantes, M (Author) Other; Zaridze, D (Author) Other; Maximovitch, D (Author) Other; Pourfarzi, F (Author) Other; Zhang, Z (Author) Other; Yu, G (Author) Other; Pakseresht, M (Author) Other; Ye, W (Author) Other; Plymoth, A (Author) Other; Leja, M (Author) Other; Gasenko, E (Author) Other; Derakhshan, MH (Author) Other; Negri, E (Author) Other; La Vecchia, C (Author) Other; Peleteiro, B (Author) Other; Lunet N (Author) FMUP

Journal

Title: European Journal of Cancer Prevention

Vol. 28

Pages: 390-396

ISSN: 0959-8278

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00Q-ZP3

DOI: 10.1097/cej.0000000000000471

Abstract (EN): Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case-control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis. Heterogeneity was quantified using the I-2 statistic and publication bias with Egger's test. There was no significant association between smoking (ever vs. never) and H. pylori seropositivity (adjusted odds ratio = 1.08; 95% CI: 0.89-1.32; adjusted PR = 1.01; 95% CI: 0.98-1.05). The strength of the association did not increase with the intensity or duration of smoking; stratified analyses according to sex, age, region or type of sample did not yield a consistent pattern of variation or statistically significant results, except for participants younger than 55 years and who had been smoking for more than 30 years (adjusted PR = 1.08; 95% CI: 1.02-1.15). This is the first collaborative analysis providing pooled estimates for the association between smoking and H. pylori seropositivity, based on detailed and uniform information and adjusting for major covariates. The results do not support an association between smoking and H. pylori infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7