Modifiable factors and esophageal cancer: a systematic review of published meta-analyses

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Castro, C (Author) Other; peleteiro, b (Author) FMUP; Lunet N (Author) FMUP

Journal

Title: Journal of Gastroenterology

Vol. 53

Pages: 37-51

ISSN: 0944-1174

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 57 Citations

Scopus - 70 Citations

Other information

Authenticus ID: P-00M-XR1

DOI: 10.1007/s00535-017-1375-5

Abstract (EN): There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and mat, drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. Cessation of drinking and smoking significantly reduced ESCC risk. For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C. Differences in results between meta-analyses and mechanisms underlying some of the associations found are discussed. This work reinforces the importance of a separate assessment of EC subtypes to allow for a proper evaluation of incidence trends and planning of prevention/control interventions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15