Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Ferro, A (Author) Other; Costa, AR (Author) Other; Morais, S (Author) Other; Bertuccio, P (Author) Other; Rota, M (Author) Other; Pelucchi, C (Author) Other; Hu, JF (Author) Other; Johnson, KC (Author) Other; Zhang, ZF (Author) Other; Palli, D (Author) Other; Ferraroni, M (Author) Other; Yu, GP (Author) Other; Bonzi, R (Author) Other; peleteiro, b (Author) FMUP; Lopez Carrillo, L (Author) Other; Tsugane, S (Author) Other; Hamada, GS (Author) Other; Hidaka, A (Author) Other; Malekzadeh, R (Author) Other; Zaridze, D (Author) Other; Maximovich, D (Author) Other; Vioque, J (Author) Other; Navarrete Munoz, EM (Author) Other; Alguacil, J (Author) Other; Castano Vinyals, G (Author) Other; Wolk, A (Author) Other; Hakansson, N (Author) Other; Ulises Hernandez Ramirez, RU (Author) Other; Pakseresht, M (Author) Other; Ward, MH (Author) Other; Pourfarzi, F (Author) Other; Mu, LN (Author) Other; Lopez Cervantes, M (Author) Other; Persiani, R (Author) Other; Kurtz, RC (Author) Other; Lagiou, A (Author) Other; Lagiou, P (Author) Other; Boffetta, P (Author) Other; Boccia, S (Author) Other; Negri, E (Author) Other; Camargo, MC (Author) Other; Curado, MP (Author) Other; La Vecchia, C (Author) Other; Lunet N (Author) FMUP

Journal

Title: International Journal of Cancer

Vol. 147

Pages: 3090-3101

ISSN: 0020-7136

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-00S-CJG

DOI: 10.1002/ijc.33134

Abstract (EN): A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12