Subcutaneous fat mass in infancy and cardiovascular risk factors at school-age: The generation R study

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Santos, S (Author) Other; Gaillard, R (Author) Other; Oliveira A (Author) FMUP; Barros H (Author) FMUP; Hofman, A (Author) Other; Franco, OH (Author) Other; Jaddoe, VWV (Author) Other

Journal

Title: Obesity

Vol. 24 No. 10

Pages: 424-429

ISSN: 1930-7381

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00K-3JH

DOI: 10.1002/oby.21343

Abstract (EN): ObjectiveTo examine the associations of infant subcutaneous fat with cardiovascular risk factors at school-age. MethodsIn a population-based prospective cohort study among 808 children, total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total subcutaneous fat) at 1.5 and 24 months were estimated. At 6 years, body mass index, blood pressure, cholesterol, triglycerides, and insulin levels were measured. ResultsInfant subcutaneous fat measures were not associated with childhood blood pressure, triglycerides, or insulin levels. A 1-standard-deviation score (SDS) higher total subcutaneous fat at 1.5 months was, independently of body mass index, associated with lower low-density lipoprotein (LDL)-cholesterol levels at 6 years. In contrast, a 1-SDS higher total subcutaneous fat at 24 months was associated with higher total-cholesterol [difference 0.13 (95% confidence interval (CI) 0.03, 0.23) SDS] and LDL-cholesterol levels [difference 0.12 (95% CI 0.02, 0.21) SDS] at 6 years. There were no associations of central-to-total subcutaneous fat ratio with childhood cholesterol levels. ConclusionsThese results suggest that infant total subcutaneous fat is weakly associated with cholesterol levels at school-age. Further studies are needed to assess the long-term cardiometabolic consequences of infant body fat.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6