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Anthocyanins as Antidiabetic Agents-In Vitro and In Silico Approaches of Preventive and Therapeutic Effects

Title
Anthocyanins as Antidiabetic Agents-In Vitro and In Silico Approaches of Preventive and Therapeutic Effects
Type
Another Publication in an International Scientific Journal
Year
2020
Authors
Fernandes, A
(Author)
Other
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Natercia F Bras
(Author)
FCUP
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Victor de Freitas
(Author)
FCUP
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Journal
Title: MoleculesImported from Authenticus Search for Journal Publications
Vol. 57
Final page: 3813
ISSN: 1420-3049
Publisher: MDPI
Other information
Authenticus ID: P-00S-MMR
Abstract (EN): Many efforts have been made in the past two decades into the search for novel natural and less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to anthocyanins, although different factors like the food source, the amount ingested, the matrix effect and the time of consumption (before or after a meal) seem to result in contradictory conclusions. The possible mechanisms involved in these preventive or therapeutic effects will be discussed-giving emphasis to the latest in vitro and in silico approaches. Therapeutic strategies to counteract metabolic alterations related to hyperglycemia and Type 2 Diabetes Mellitus (T2DM) may include: (a) Inhibition of carbohydrate-metabolizing enzymes; (b) reduction of glucose transporters expression or activity; (c) inhibition of glycogenolysis and (d) modulation of gut microbiota by anthocyanin breakdown products. These strategies may be achieved through administration of individual anthocyanins or by functional foods containing complexes of anthocyanin:carbohydrate:protein.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 30
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