Oncocytic thyroid neoplasms: from histology to molecular biology

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Canberk, S (Author) Other; Lima, AR (Author) Other; Correia, M (Author) Other; Batista, R (Author) Other; Soares, P (Author) FMUP; Maximo, V (Author) FMUP; Simões, MS (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Diagnostic Histopathology

Vol. 25

Pages: 154-165

ISSN: 1756-2317

Indexing

Scopus - 7 Citations

Other information

Authenticus ID: P-00R-W6X

DOI: 10.1016/j.mpdhp.2019.02.002

Abstract (EN): The recent update of the 4th edition of the World Health Organization's Classification of Tumors of Endocrine Organs introduced important changes in the nomenclature of follicular-cell thyroid tumors, namely, regarding mitochondrion-rich neoplasms (In this review, for the practical purposes, the words Hürthle and oncocytic are synonymous in the field of thyroid pathology.) According to the last edition, oncocytic thyroid neoplasms, with follicular architecture and no typical nuclei of papillary carcinoma, ¿ are now included in a separate group - the Hürthle cell neoplasms. Whenever thus categorized-while keeping oncocytic variant of papillary, medullary and poorly differentiated carcinoma-, a sort of tidal phenomenon has occurred about oncocytic tumors known for decades. Through this categorization, pathologists and researchers need to progress in the discussion about etiopathogenesis of oncocytic neoplasms (ONs). This review provides an attempt to balance the facts and doubts by questioning the recent changes based on what is known about oncocytic tumors. © 2019

Language: English

Type (Professor's evaluation): Scientific