Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Cavadas, B (Author) Other; Pereira, JB (Author) Other; Correia, M (Author) Other; Fernandes, V (Author) Other; Eloy, C (Author) Other; Sobrinho Simoes, M (Author) Other; Soares, P (Author) FMUP; Samuels, DC (Author) Other; Maximo, V (Author) FMUP; Pereira, L (Author) Other

Journal

Title: Mitochondrion

Vol. 46

Pages: 123-133

ISSN: 1567-7249

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00N-W19

DOI: 10.1016/j.mito.2018.04.001

Abstract (EN): We conducted the first systematic omits study of the oncocytic phenotype in 488 papillary thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is secondary to PTC, being unrelated to several pathologic scores. The nuclear genome had low impact on this phenotype (except in specific copy number variation), which was mostly driven by the significant accumulation of mitochondrial DNA non-synonymous and frameshift mutations at high heteroplasmy levels. Energy and mitochondrial-related pathways were significantly enriched in oncocytic tumors that also displayed increased levels of expression for genes involved in autophagy and fusion of mitochondria. Our in vitro tests confirmed that autophagy is increased and functional while mitophagy is decreased in these tumors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11