Advanced Biomaterials and Processing Methods for Liver Regeneration: State-of-the-Art and Future Trends

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Morais, AD (Author) Other; Vieira, S (Author) Other; Zhao, XL (Author) Other; Mao, ZW (Author) Other; Gao, CY (Author) Other; Oliveira, JM (Author) Other; Rui Reis (Author) Other

Journal

Title: Advanced healthcare materials

Vol. 9

ISSN: 2192-2640

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 32 Citations

Other information

Authenticus ID: P-00R-NKF

DOI: 10.1002/adhm.201901435

Abstract (EN): Liver diseases contribute markedly to the global burden of mortality and disease. The limited organ disposal for orthotopic liver transplantation results in a continuing need for alternative strategies. Over the past years, important progress has been made in the field of tissue engineering (TE). Many of the early trials to improve the development of an engineered tissue construct are based on seeding cells onto biomaterial scaffolds. Nowadays, several TE approaches have been developed and are applied to one vital organ: the liver. Essential elements must be considered in liver TE-cells and culturing systems, bioactive agents or growth factors (GF), and biomaterials and processing methods. The potential of hepatocytes, mesenchymal stem cells, and others as cell sources is demonstrated. They need engineered biomaterial-based scaffolds with perfect biocompatibility and bioactivity to support cell proliferation and hepatic differentiation as well as allowing extracellular matrix deposition and vascularization. Moreover, they require a microenvironment provided using conventional or advanced processing technologies in order to supply oxygen, nutrients, and GF. Herein the biomaterials and the conventional and advanced processing technologies, including cell-sheets process, 3D bioprinting, and microfluidic systems, as well as the future trends in these major fields are discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 26