Cardiac biomarkers in neonatology: BNP/NTproBNP, troponin I/T, CK-MB and myoglobin - a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Teixeira, RP (Author) Other; Neves AL (Author) FMUP; Guimarães H (Author) FMUP

Journal

Title: Journal of Pediatric and Neonatal Individualized Medicine

Vol. 6

Publisher: Hygeia Press di Corridori Marinella

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00N-91Z

DOI: 10.7363/060219

Abstract (EN): Cardiac biomarkers play a central role in myocardial injury and heart failure in adult patients, but their clinical relevance in neonatolmy has not been clearly stablished. The aim of this systematic review was to evaluate the recent literature on B-type natriuretic peptide (BNP)/N-terminal-pro-BNP (NTproBNP), troponin I/T, Creatine Kinase-MB (CK-MB) and myoglobin and their relationship with different pathologies of the newborn. A total of 67 articles were included to undergo data extraction, after a first text and abstract analysis and a second full-text analysis, using the PubMed database. Evidence shows that cardiac biomarkers are a useful and fast diagnostic tool with great potential for becoming as important as clinical and echocardiographic findings in pathologies of the heart. BNP/NTproBNP and troponin UT demonstrated to be the ones with greater value. BNP/NTproBNP is of particular significance in the diagnosis and management of patent ductus arteriosus, as it has a good correlation with diagnosis, treatment and prognosis. Troponin T may be a beneficial additional marker for this disease, correlating with ductal significance and treatment response. Moreover. BNP/NTproBNP can he used, with other clinical and laboratory findings, in the diagnosis and as a guide for treatment in pulmonary hypertension and in the diagnosis and management of cardiac sequela in bronchopulmonary dysplasia. Troponin I/T finds its clinical importance in perinatal asphyxia as a marker of myocardial injury and a reliable indicator of severity and mortality. Further studies with larger cohort populations are needed for stablishing the cutoff values specific for each neonatal pathology allowing its early and proper management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18