Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants

• Type: Article in International Scientific Journal
• Date: 1992

Authors

Denjean, A (Author) Other; Guimarães H (Author) FMUP; Migdal, M (Author) Other; Miramand, JL (Author) Other; Dehan, M (Author) Other; Gaultier, C (Author) Other

Journal

Title: Journal of Pediatrics

Vol. 120

Pages: 974-979

ISSN: 0022-3476

Publisher: Elsevier

Indexing

Scopus - 59 Citations

Other information

Authenticus ID: P-008-Q3N

DOI: 10.1016/s0022-3476(05)81973-0

Abstract (EN): We used a placebo-controlled standardized protocol to define the dose-response relationship to the ß-adrenergic bronchodilator salbutamol (albuterol) in 10 ventilator-dependent premature infants at a postnatal age of 13.3 ± 4.9 days. Passive respiratory system resistance and compliance were measured at baseline and 10 minutes after administration of salbutamol via a metered-dose inhaler and spacer device. Salbutamol caused a significant dose-related response with a 33% mean decrease in respiratory system resistance (p < 0.05) and a 67% mean increase in respiratory system compliance (p < 0.001). In seven and six patients, respectively, 100 ¿g of salbutamol caused significant improvement in resistance and compliance; 200 ¿g was required in the remainder, but one patient had no improvement in compliance. Oxygen saturation increased linearly with the increase in compliance. In 7 of the 10 infants, the duration of action of 200 ¿g of salbutamol on the following day was 3 hours. We conclude that bronchodilator treatment may be useful in the management of ventilator-dependent neonates with respiratory distress syndrome.

Language: English

Type (Professor's evaluation): Scientific