Genetic factors in chronic lung disease in neonates. Preliminary results

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Guimarães H (Author) Other; Xavier, P (Author) Other; Mateus, M (Author) Other; D'Orey, C (Author) Other; Souto, A (Author) Other; Teixeira Santos, N (Author) Other; Mendes, A (Author) Other

Journal

Title: Pediatric Pulmonology

Vol. 24

Final page: 302

ISSN: 8755-6863

Publisher: Wiley-Blackwell

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-007-G5C

Abstract (EN): Chronic lung disease (CLD) in newboms has been associated with prematurity, mechanical ventilation and high inspired oxygen concentration. However only a small percentage of premature infants treated with mechanical ventilation and oxygen therapy develop chronic lung disease, with several grades of severity. This suggests that genetic factors predispose some prematures to develop CLD. The aim of this study was to determine the HLA types of premature infants with CLD and correlate those findings with the clinical course of these patients. Material and Methods: HLA phenotypes were determined on 17 newborn infants weighing less than 1500g and oxygen dependent at 36 weeks postconceptional age and on 2384 healthy controls. We carried out typing of 18 HLA-A and 32 HLA-B antigens by microlymphocytotoxic test. Results: The antigen B13 shows to have statistic significance after the correction p (X2 = 11,29, p = 0,00078, pc = 0,025, Fisher's tests : p = 0,00078 and RR (Relative Risk) = 6,6. We concluded, with our preliminary results, that genetic factors (HLA types) seem to have some role on development of CLD in prematurity. © 1997 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific