Neonatal Alloimmune Neutropenia: Still a Diagnostic and Therapeutical Challenge

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Agueda, S (Author) Other; Rocha, G (Author) Other; Ferreira, F (Author) Other; Vitor, B (Author) Other; Lima, M (Author) ICBAS; Guimarães H (Author) FMUP

Journal

Title: Journal of Pediatric Hematology/Oncology

Vol. 34

Pages: 497-499

ISSN: 1077-4114

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-002-54V

DOI: 10.1097/mph.0b013e318266c3b5

Abstract (EN): Objective: To describe a case of neonatal alloimmune neutropenia (NAN), a very rare disease of the newborn and the first ever reported in our neonatal intensive care unit, with emphasis in its management and outcome. Description: We report a case of NAN due to anti-human neutrophil antigen-1b alloimmunization in a 29-week preterm admitted to our neonatal intensive care unit. In this case, the neutropenia was severe and persisted for almost 2 months. There was a good response to the administration of intravenous immunoglobulin. Comments: NAN is caused by maternal production of neutrophilspecific alloantibodies in response to antigens from paternal heritage present on the newborn neutrophiles. The course of the disease is usually mild and self-limiting. The optimal therapy is yet a debate, with some authors finding the use of intravenous immunoglobulin effective, prophylactic antibiotic therapy or recombinant human granulocyte colony-stimulating factor.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3