Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Benninger, Y (Author) Other; Thurnherr, T (Author) Other; Pereira, JA (Author) Other; Krause, S (Author) Other; Wu, X (Author) Other; Chrostek Grashoff, A (Author) Other; Herzog, D (Author) Other; Nave, KA (Author) Other; Franklin, RJM (Author) Other; Meijer, D (Author) Other; Brakebusch, C (Author) Other; Suter, U (Author) Other; Relvas, JB (Author) Other

Journal

Title: Journal of Cell Biology

Vol. 177

Pages: 1051-1061

ISSN: 0021-9525

Publisher: Rockefeller University Press

Indexing

ISI Web of Knowledge - 119 Citations

Scopus - 143 Citations

Other information

Authenticus ID: P-005-708

DOI: 10.1083/jcb.200610108

Abstract (EN): During peripheral nervous system ( PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11